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Since many individuals with Down syndrome have recurrent respiratory tract infections, we studied the bacterial adhesion in a group of Free text to Hastings in comparison to control subjects.

Exfoliated buccal epithelial cells were incubated with Staphylococcus aureus ATCC and ga mean number of adhering bacteria per cell was counted under scanning electron microscope.

Results : the Down syndrome and the control groups prone to recurrent respiratory infections showed both higher adhesion values in comparison to groups without recurrent respiratory tract infections.

Moreover, the Down subjects without recurrent respiratory infections had bacterial adhesion values to buccal epithelial cells similar to control subjects.

Conclusions : The increased bacterial adhesion values in Down and control subjects prone to recurrent respiratory tract infections is probably attributable to an increased expression of cell receptors for bacteria. Bacterial adhesion; Staphylococcus aureus; buccal cells; Down syndrome; recurrent respiratory tract infections.

Keywords : Bacterial adhesion; Staphylococcus aureus; buccal cells; Down syndrome; recurrent respiratory tract infections. In Italy, the prevalence is approximately 1 in 2. DS in characterized by a variety of dysmorphic features associated with several immunological impairments that might explain the increased incidence of leukemia, celiac disease, hypothyroidism and diabetes mellitus.

People with DS have a higher Huddrrsfield rate for respiratory infections, approximately twice than that observed in individuals of the Aromatherapy massage Kingswood age [2]. The respiratory infections and congenital heart defects CHD are the two most frequently reported causes of death []: in particular, bronchopneumonia is the most frequent cause in older subjects, while for younger ones is heart disease [6].

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In their course of life, this population also has a higher incidence of respiratory infections, stesm tends to increase with age [3]. The upper respiratory tract is the most affected: rhinosinusitis, pharyngitis and effusive otitis media are common.

The lower respiratory tract infections are one of the most common causes of hospitalization in this population, regardless of the coexistence or not of CHD [7, 8] and respiratory infections, especially pneumonia, are more frequent when the subjects are institutionalized Bradford escort marina bay sands. Even through some Dillons russian steam Huddersfield gay children may not present frequent infections RRTI -the course of their infective illnesses might be prolonged and have increased severity compared with non-DS children [10, 11].

Published guidelines [13] include recommendations for the follow-up of the increased susceptibility to respiratory infections in DS, especially in children. A few data on microbial etiology are available in patients with DS, although it is considered that most respiratory infections, especially of the upper respiratory tract, are caused by viruses, as it is for general population.


Respiratory viral infections, on the other hand, predispose the individual to bacterial secondary infections by promoting bacterial adhesion [14, 15]. Streptococcus pneumoniaeHaemophilus influentiae and Moraxella catharralis are the three most common bacteria known to cause otitis media and pneumonia in children Naughty nuru Rossendale.

The pathophysiology underlying the increased risk for respiratory disease in DS remains unclear, even if multiple abnormalities, such as hypotonia, developmental delay, craniofacial shape and CHD may contribute [17].

In addition, several studies have shown some abnormalities in the immunoglobulin levels, as decreased salivary IgA and IgG and IgG4 subclass deficiency is common finding in DS patients with recurrent infections [18, 19].

Chronic aspiration is another cause that could explain the recurrent respiratory symptoms in DS patients [20].