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Drug interactions between antiretroviral drugs ARVs and anthelminthic drugs, ivermectin IVM and praziquantel PZQ were assessed by investigating their permeation through the Caco-2 cell cornig in a transwell. The reverse was conducted for the assessment of Jaguars gentlemans club Littlehampton influence of ARVs on anthelminthics. Samples from the AP and BL compartments were taken at 60,and min and quantified either by HPLC or radiolabeled assay using a liquid scintillating counter for the respective drugs.

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Expert Opin Drug Metab Toxicol. In coening system, the passage of drugs from apical AP to basolateral BL compartment is attributable to passive diffusion and occurs at a lower rate, whereas the BL to AP passage occurs by active transport, presumed to be mediated by transporters [ 204464 ].

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Inhibition of human cytochrome P isoforms by nonnucleoside reverse transcriptase inhibitors. Ketoconazole, a CYP inhibitor has been reported to double the Massage kingsway Stockport concentration of PZQ in humans, while rifampicin; an inducer has been reported to dramatically reduce its concentration, and the authors recommended dose adjustment upon co-administration [ 4143 ].

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